Publications that include data obtained in the NMR Facility


The instrumentation in the AECOM Structural NMR Resource is supported by the Albert Einstein College of Medicine and in part by grants from the NSF (DBI9601607 and DBI0331934) and the NIH (RR017998). NMR operations at NYSBC are supported by the member institutions and by NIH P41 GM66354.

74. Quartararo, C. E., T. Hadi, S. M. Cahill and J. S. Blanchard (2013). "Solvent Isotope-Induced Equilibrium Perturbation for Isocitrate Lyase." Biochemistry 52(51): 9286-9293.

73. Regula, L. K., R. Harris, F. Wang, C. D. Higgins, J. F. Koellhoffer, Y. Zhao, K. Chandran, J. M. Gao, M. E. Girvin and J. R. Lai (2013). "Conformational Properties of Peptides Corresponding to the Ebolavirus GP2 Membrane-Proximal External Region in the Presence of Micelle-Forming Surfactants and Lipids." Biochemistry 52(20): 3393-3404.

72. Janda, A., E. Eryilmaz, A. Nakouzi, D. Cowburn and A. Casadevall (2012). "Variable Region Identical Immunoglobulins Differing in Isotype Express Different Paratopes." Journal of Biological Chemistry 287(42): 35409-35417.

71. Shah, N. H., E. Eryilmaz, D. Cowburn and T. W. Muir (2013). "Extein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans-Splicing." Journal Of The American Chemical Society 135(15): 5839-5847.

70. Suarez, J., Antti M. Haapalainen, Sean M. Cahill, M.-C. Ho, F. Yan, Steven C. Almo and Vern L. Schramm (2013). "Catalytic Site Conformations in Human PNP by 19F-NMR and Crystallography." Chemistry & Biology 20(2): 212-222. Article (PDF)

69. Kalmatsky, B. D., Y. Batir, T. A. Bargiello and T. L. Dowd (2012). "Structural studies of N-terminal mutants of Connexin 32 using (1)H NMR spectroscopy." Archives of Biochemistry and Biophysics 526(1): 1-8. Article (PDF)

68. Bhattacharya, S., H. T. Zhang, D. Cowburn and A. K. Debnath (2012). "Novel structures of self-associating stapled peptides." Biopolymers 97(5): 253-264. Article (PDF)

67. Patel, V. L., S. Mitra, R. Harris, A. R. Buxbaum, T. Lionnet, M. Brenowitz, M. Girvin, M. Levy, S. C. Almo, R. H. Singer and J. A. Chao (2012). "Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control." Genes & Development 26(1): 43-53. Article (PDF)

66. Zhao, F., M. Ilbert, R. Varadan, C. M. Cremers, B. Hoyos, R. Acin-Perez, V. Vinogradov, D. Cowburn, U. Jakob and U. Hammerling (2011). "Are Zinc-Finger Domains of Protein Kinase C Dynamic Structures That Unfold by Lipid or Redox Activation?" Antioxidants & Redox Signaling 14(5): 757-766. Article (PDF)

65. Zhang, H. T., F. Curreli, X. H. Zhang, S. Bhattacharya, A. A. Waheed, A. Cooper, D. Cowburn, E. O. Freed and A. K. Debnath (2011). "Antiviral activity of alpha-helical stapled peptides designed from the HIV-1 capsid dimerization domain - art. no. 28." Retrovirology 8: 28. Article (PDF)

64. Kaoud, T. S., A. K. Devkota, R. Harris, M. S. Rana, O. Abramczyk, M. Warthaka, S. Lee, M. E. Girvin, A. F. Riggs and K. N. Dalby (2011). "Activated ERK2 Is a Monomer in Vitro with or without Divalent Cations and When Complexed to the Cytoplasmic Scaffold PEA-15." Biochemistry 50(21): 4568-4578. Article (PDF)

63. Schweitzer, A. D., E. Revskaya, P. Chu, V. Pazo, M. Friedman, J. D. Nosanchuk, S. Cahill, S. Frases, A. Casadevall and E. Dadachova (2010). "MELANIN-COVERED NANOPARTICLES FOR PROTECTION OF BONE MARROW DURING RADIATION THERAPY OF CANCER." International Journal of Radiation Oncology Biology Physics 78(5): 1494-1502. Article (PDF)

62. Lefurgy, S. T., S. B. Rodriguez, C. S. Park, S. Cahill, R. B. Silverman and T. S. Leyh (2010). "Probing Ligand-binding Pockets of the Mevalonate Pathway Enzymes from Streptococcus pneumoniae." Journal of Biological Chemistry 285(27): 20654-20663. Article (PDF)

61. Reuther, G., R. Harris, M. Girvin and T. S. Leyh (2010). "Backbone 1H, 13C, 15N NMR assignments of the unliganded and substrate ternary complex forms of mevalonate diphosphate decarboxylase from Streptococcus pneumoniae." Biomolecular NMR Assignments Online Edition. Article (PDF)

60. Poget, S., R. Harris, S. M. Cahill and M. E. Girvin (2010). "1H, 13C, 15N backbone NMR assignments of the Staphylococcus aureus small multidrug-resistance pump (Smr) in a functionally active conformation." Biomolecular NMR Assignments Online Edition. Article (PDF)

59. Wu, H. Y., S. C. Shekar, R. J. Flinn, M. El-Sibai, B. S. Jaiswal, K. I. Sen, V. Janakiraman, S. Seshagiri, G. J. Gerfen, M. E. Girvin and J. M. Backer (2009). "Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110 alpha and are disrupted in oncogenic p85 mutants." Proceedings Of The National Academy Of Sciences Of The United States Of America 106(48): 20258-20263. Article (PDF)

58. Sikora, A. L., S. M. Cahill and J. S. Blanchard (2009). "Enterobactin Synthetase-Catalyzed Formation of P-1,P-3-Diadenosine-5 '-tetraphosphate." Biochemistry 48(46): 10827-10829. Article (PDF)

57. Ghanem, M., A. S. Murkin and V. L. Schramm (2009). "Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase." Chemistry & Biology 16(9): 971-979. Article (PDF)

56. Kalmatsky, B. D., S. Bhagan, Q. Tang, T. A. Bargiello and T. L. Dowd (2009). "Structural studies of the N-terminus of Connexin 32 using 1H NMR spectroscopy." Archives of Biochemistry and Biophysics 490(1): 9-16. Article (PDF)

55. Leu, J., M.-H. Cui, H. Shamoon and I. Gabriely (2009). "Hypoglycemia-Associated Autonomic Failure Is Prevented by Opioid Receptor Blockade." J Clin Endocrinol Metab 94(9): 3372-3380. Article (PDF)

54. McLachlan, G. D., J. Slocik, R. Mantz, D. Kaplan, S. Cahill, M. Girvin and S. Greenbaum (2009). "High-resolution NMR characterization of a spider-silk mimetic composed of 15 tandem repeats and a CRGD motif." Protein Science 18(1): 206-216. Article (PDF)

53. Dadachova, E., J. Rivera, E. Revskaya, A. Nakouzi, S. M. Cahill, M. Blumenstein, H. Xiao, D. Rykunov and A. Casadevall (2008). "In vitro evaluation, biodistribution and scintigraphic imaging in mice of radiolabeled anthrax toxins." Nuclear Medicine And Biology 35(7): 755-761. Article (PDF)

52. Magalhaes, M. L. B., A. Argyrou, S. M. Cahill and J. S. Blanchard (2008). "Kinetic and mechanistic analysis of the Escherichia coli ribD-encoded bifunctional deaminase-reductase involved in riboflavin biosynthesis." Biochemistry 47(24): 6499-6507. Article (PDF)

51. Meng, F., B. N. Manjula, P. K. Smith and S. A. Acharya (2008). "PEGylation of human serum albumin: Reaction of PEG-phenyl-isothiocyanate with protein." Bioconjugate Chemistry 19(7): 1352-1360. Article (PDF)

50. Shekar, S. C., J. M. Backer and M. E. Girvin (2008). "Effectively doubling the magnetic field in spin-1/2-spin-1, HSQC, HDQC, coupled HSQC, and coupled HDQC in solution NMR - art. no. 184501." Journal Of Chemical Physics 128(18): 84501-84501. Article (PDF)

49. Zhang, Q., H. S. Atreya, D. E. Kamen, M. E. Girvin and T. Szyperski (2008). "GFT projection NMR based resonance assignment of membrane proteins: application to subunit c of E-coli F1F0 ATP synthase in LPPG micelles." Journal Of Biomolecular Nmr 40(3): 157-163. Article (PDF)

48. Ananda, K., P. Nacharaju, P. K. Smith, S. A. Acharya and B. N. Manjula (2008). "Analysis of functionalization of methoxy-PEG as maleimide-PEG." Analytical Biochemistry 374(2): 231-242. Article (PDF)

47. Ghanem, M., S. Saen-Oon, N. Zhadin, C. Wing, S. M. Cahill, S. D. Schwartz, R. Callender and V. L. Schramm (2008). "Tryptophan-free human PNP reveals catalytic site interactions." Biochemistry 47(10): 3202-3215. Article (PDF)

46. Wakata, A., S. M. Cahill, M. Blumenstein, R. H. Gunby, S. Jockusch, A. A. Marti, B. Cimbro, C. Gambacorti-Passerini, A. Donella-Deana, L. A. Pinna, N. J. Turro and D. S. Lawrence (2008). "A mechanistic design principle for protein tyrosine kinase sensors: Application to a validated cancer target." Organic Letters 10(2): 301-304. Article (PDF)

45. Poget, S. F. and M. E. Girvin (2007). "Solution NMR of membrane proteins in bilayer mimics: Small is beautiful, but sometimes bigger is better." Biochimica Et Biophysica Acta-Biomembranes 1768(12): 3098-3106. Article (PDF)

44. McLachlan, G. D., S. M. Cahill, M. E. Girvin and S. C. Almo (2007). "Acid-induced equilibrium folding intermediate of human platelet profilin." Biochemistry 46(23): 6931-6943. Article (PDF)

43. Poget, S. F., S. M. Cahill and M. E. Girvin (2007). "Isotropic bicelles stabilize the functional form of a small multidrug-resistance pump for NMR structural studies." Journal Of The American Chemical Society 129(9): 2432. Article (PDF)

42. Kamen, D. E., S. M. Cahill and M. E. Girvin (2007). "Multiple alignment of membrane proteins for measuring residual dipolar couplings using lanthanide ions bound to a small metal chelator." Journal Of The American Chemical Society 129(7): 1846-1847. Article (PDF)

41. Wang, Q. Z., Z. H. Dai, S. M. Cahill, M. Blumenstein and D. S. Lawrence (2006). "Light-regulated sampling of protein tyrosine kinase activity." Journal Of The American Chemical Society 128(43): 14016-14017. Article (PDF)

40. de Carvalho, L. P. S. and J. S. Blanchard (2006). "Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis." Biochemistry 45(29): 8988-8999. Article (PDF)

39. Poget, S., S. Krueger-Koplin, R. Krueger-Koplin, S. Cahill, S. Chandra Shekar and M. Girvin (2006). "NMR Assignment of the Dimeric S. aureus Small Multidrug-Resistance Pump in LPPG Micelles." Journal of Biomolecular NMR 36(Supplement 1): 10. Article (PDF)

38. Lewis, B. E., N. Choytun, V. L. Schramm and A. J. Bennett (2006). "Transition states for glucopyranose interconversion." Journal Of The American Chemical Society 128(15): 5049-5058. Article (PDF)

37. Wang, Q. Z., S. M. Cahill, M. Blumenstein and D. S. Lawrence (2006). "Self-reporting fluorescent substrates of protein tyrosine kinases." Journal Of The American Chemical Society 128(6): 1808-1809. Article (PDF)

36. Amukele, T. K., S. Roday and V. L. Schramm (2005). "Ricin A-chain activity on stem-loop and unstructured DNA substrates." Biochemistry 44(11): 4416-4425. Article (PDF)

35. Lee, S. Y., F. Liang, X.-L. Guo, L. Xie, S. M. Cahill, M. Blumenstein, H. Yang, D. S. Lawrence and Z.-Y. Zhang (2005). "Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor." Angewandte Chemie-International Edition 44(27): 4242-4244. Article (PDF)

34. Shekar, S. C., H. Y. Wu, Z. Fu, S.-C. Yip, Nagajyothi, S. M. Cahill, M. E. Girvin and J. M. Backer (2005). "Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit." Journal Of Biological Chemistry 280(30): 27850-27855. Article (PDF)

33. Kamen, D. E., S. T. Gross, M. E. Girvin and D. W. Wilson (2005). "Structural basis for the physiological temperature dependence of the association of VP16 with the cytoplasmic tail of herpes simplex virus glycoprotein H." Journal Of Virology 79(10): 6134-6141. Article (PDF)

32. Deng, H., S. M. Cahill, J. L. Abad, A. Lewandowicz, R. H. Callender, V. L. Schramm and R. A. Jones (2004). "Active site contacts in the purine nucleoside phosphorylase - Hypoxanthine complex by NMR and ab initio calculations." Biochemistry 43(50): 15966. Article (PDF)

31. Rivera-Torres, I. O., R. D. Krueger-Koplin, D. B. Hicks, S. M. Cahill, T. A. Krulwich and M. E. Girvin (2004). "pKa of the essential Glu54 and backbone conformation for subunit c from the H+-coupled F1F0 ATP synthase from an alkaliphilic Bacilus." FEBS Letters 575: 131-135. Article (PDF)

30. Deng, H., A. Lewandowicz, S. M. Cahill, R. H. Furneaux, P. C. Tyler, M. E. Girvin, R. H. Callender and V. L. Schramm (2004). "Assignment of downfield proton resonances in purine nucleoside phosphorylase center dot immucillin-H complex by saturation-transferred NOEs." Biochemistry 43(7): 1980. Article (PDF)

29. Deng, H., S. Cahill, L. Kurz and R. Callender (2004). "The assignment of downfield proton resonances in an enzyme inhibitor complex using time-dependent saturation transferred NOEs." Journal of the American Chemical Society 126(7): 1952. Article (PDF)

28. Krueger-Koplin, R. D., P. L. Sorgen, S. T. Krueger-Koplin, A. O. Rivera-Torres, S. M. Cahill, D. B. Hicks, L. Grinius, T. A. Krulwich and M. E. Girvin (2004). "An evaluation of detergents for NMR structural studies of membrane proteins." Journal of Biomolecular NMR 28(1): 43-57. Article (PDF)

27. Dowd, T. L., J. F. Rosen, L. Li, C. M. Gundberg (2003). "The Three-Dimensional Structure of Bovine Calcium Ion-Bound Ostoecalcin Using 1H NMR Spectroscopy." Biochemistry 42(19): 7769-7779. Article (PDF)

26. Sauve, A. A., S. M. Cahill, S. G. Zech, L. A. Basso, A. Lewandowicz, D. S. Santos, C. Grubmeyer, G. B. Evans, R. H. Furneaux, P. C. Tyler, A. McDermott, M. E. Girvin, V. L. Schramm (2003). "Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases." Biochemistry 42(19): 5694. Article (PDF)

25. Sugantino, M., R. J. Zheng, M. Yu and J. S. Blanchard (2003). "Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: Tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids." Biochemistry 42(1): 191. Article (PDF)

24. Kicska, G. A., P. C. Tyler, G. B. Evans, R. H. Furneaux, W. X. Shi, A. Fedorov, A. Lewandowicz, S. M. Cahill, S. C. Almo and V. L. Schramm (2002). "Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase." Biochemistry 41(49): 14489-14498. Article (PDF)

23. Duffy, H. S., P. L. Sorgen, M. E. Girvin, P. O'Donnell, W. Coombs, S. M. Taffet, M. Delmar and D. C. Spray (2002). "pH-Dependent Intramolecular Binding and Structure Involving Cx43 Cytoplasmic Domains." Journal of Biological Chemistry 277: 36706-36714. Article (PDF)

22. Sorgen, P. L., H. S. Duffy, S. M. Cahill, W. Coombs, D. C. Spray, M. Delmar and M. E. Girvin (2002). "Letter to the Editor: Sequence-specific resonance assignment of the carboxyl terminal domain of Connexin43." Journal of Biomolecular NMR 23(3): 245-246. Article (PDF)

21. Desamero, R. Z. B., H. Cheng, S. Cahill, M. Girvin, H. Deng, R. Callender, P. Rath, B. Variano and J. E. Smart (2002). "Physical Properties of Compounds Promoting Oral Delivery of Macromolecular Drugs." Biopolymers (Biospectroscopy) 67: 26-40. Article (PDF)

20. Desamero, R. Z. B., H. Cheng, S. Cahill, M. Girvin, H. Deng, R. Callender, P. Rath, B. Variano and J. E. Smart (2002). "Interactions of Amidated Acids with Heparin." Biopolymers (Biospectroscopy) 67: 41-48. Article (PDF)

19. Sorgen, P. L., S. M. Cahill, R. D. Krueger-Koplin, S. T. Krueger-Koplin, C. C. Schenck and M. E. Girvin (2002). "Structure of the Rhodobacter sphaeroides Light-Harvesting 1 Beta Subunit in Detergent Micelles." Biochemistry 41(1): 31-41. Article (PDF)

18. Sauve, A. A., I. Celic, J. Avalos, H. T. Deng, J. D. Boeke and V. L. Schramm (2001). Chemistry of gene silencing: The mechanism of NAD(+)-dependent deacetylation reactions.” Biochemistry 40(51): 15456-15463. Article (PDF)

17. Zheng, R. J. and J. S. Blanchard (2001). “Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase.” Biochemistry 40(43): 12904-12912. Article (PDF)

16. Lewis, B. E. and V. L. Schramm (2001). “Conformational equilibrium isotope effects in glucose by C-13 NMR spectroscopy and computational studies.” Journal of the American Chemical Society 123(7): 1327-1336. Article (PDF)

15. Glickman, M. S., S. M. Cahill and W. R. Jacobs (2001). “The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase.” Journal of Biological Chemistry 276(3): 2228-2233. Article (PDF)

14. Dowd, T. L., J. F. Rosen, L. Mints and C. M. Gundberg (2001). “The effect of Pb2+ on the structure and hydroxyapatite binding properties of osteocalcin.” Biochimica Et Biophysica Acta-Molecular Basis of Disease 1535(2): 153-163. Article (PDF)

13. Taylor, R. M., S. D. Zakharov, J. B. Heymann, M. E. Girvin and W. A. Cramer (2000). “Folded state of the integral membrane colicin E1 immunity protein in solvents of mixed polarity.” Biochemistry 39(40): 12131-12139. Article (PDF)

12. Purnick, P. E. M., D. C. Benjamin, V. K. Verselis, T. A. Bargiello and T. L. Dowd (2000). “Structure of the amino terminus of a gap junction protein.” Archives of Biochemistry and Biophysics 381(2): 181-190. Article (PDF)

11. Mahoney, N. M., V. K. Rastogi, S. M. Cahill, M. E. Girvin and S. C. Almo (2000). “Binding orientation of proline-rich peptides in solution: Polarity of the profilin-ligand interaction.” Journal of the American Chemical Society 122(32): 7851-7852. Article (PDF)

10. Koo, C. W., A. Sutherland, J. C. Vederas and J. S. Blanchard (2000). “Identification of active site cysteine residues that function as general bases: Diaminopimelate epimerase.” Journal of the American Chemical Society 122(25): 6122-6123. Article (PDF)

9. Glickman, M. S., J. S. Cox and W. R. Jacobs (2000). “A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.” Molecular Cell 5(4): 717-727. Article (PDF)

8. Barlow, J. N. and J. S. Blanchard (2000). “Enzymatic synthesis of UDP-(3-deoxy-3-fluoro)-D-galactose and UDP-(2-deoxy-2-fluoro)-D-galactose and substrate activity with UDP-galactopyranose mutase.” Carbohydrate Research 328(4): 473-480. Article (PDF)

7. Wang, G. P., S. M. Cahill, X. H. Liu, M. E. Girvin and C. Grubmeyer (1999). “Motional dynamics of the catalytic loop in OMP synthase.” Biochemistry 38(1): 284-295. Article (PDF)

6. Shi, W. X., C. M. Li, P. C. Tyler, R. H. Furneaux, S. M. Cahill, M. E. Girvin, C. Grubmeyer, V. L. Schramm and S. C. Almo (1999). “The 2.0 angstrom structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.” Biochemistry 38(31): 9872-9880. Article (PDF)

5. Rastogi, V. K. and M. E. Girvin (1999). “Letter to the Editor: H-1, C-13, and N-15 assignments and secondary structure of the high pH form of subunit c of the F1Fo ATP synthase.” Journal of Biomolecular Nmr 13(1): 91-92. Article (PDF)

4. Rastogi, V. K. and M. E. Girvin (1999). “Structural changes linked to proton translocation by subunit c of the ATP synthase.” Nature 402(6759): 263-268. Article (PDF)

3. Li, C. M., P. C. Tyler, R. H. Furneaux, G. Kicska, Y. M. Xu, C. Grubmeyer, M. E. Girvin and V. L. Schramm (1999). “Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.” Nature Structural Biology 6(6): 582-587. Article (PDF)

2. Barlow, J. N., M. E. Girvin and J. S. Blanchard (1999). “Positional isotope exchange catalyzed by UDP-galactopyranose mutase.” Journal of the American Chemical Society 121(29): 6968-6969. Article (PDF)

1. Girvin, M. E., V. K. Rastogi, F. Abildgaard, J. L. Markley and R. H. Fillingame (1998). “Solution structure of the transmembrane H+-transporting subunit c of the F1F0 ATP synthase.” Biochemistry 37(25): 8817-8824. Article (PDF)


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Last revised: May 20, 2004