Spring 2007 (every two years)
Credits/Class Meetings: A one semester course; 3 semester hours, approximately 33 one hour lectures and 10 practical sessions in the NMR Laboratory.
Prerequisite Background: Open to all students. Some background in biochemistry is essential, and introductory coursework in physical chemistry would be helpful.
Course Description: The course will provide a working knowledge of basic NMR theory, and an extensive treatment of the application of NMR to solving biochemical problems. Topics will include one, two and three dimensional methods applied to: the covalent structure and conformation of small molecules, ligand binding and exchange rates, pKa values, enzyme mechanisms, and the structure, dynamics, and folding of nucleic acids and proteins. Formal lectures will be combined with hands-on sessions in the NMR lab. Students will be assigned projects to be completed on the NMR spectrometers. Grades will be based on completion of the laboratory projects, and a research proposal.
Note: Postdocs and others are welcome to sit in.
Contact Information:
Mark Girvin, Forchheimer 303, x2025, girvin@aecom.yu.edu
Sean Cahill, Ullmann B8, x2035, cahill@aecom.yu.edu