Graduate Biochemistry, Fall 2010
# Date Title Lecturer






Part I: Macromolecules and assemblies




1 08/23/10 Course organization and background material Bresnick
2 08/24/10 Three-dimensional structure of proteins Bresnick
3 08/25/10 Protein energetics Almo
4 08/26/10 Protein structure determination and the PDB I Almo

08/27/10 Tutorial- Molecular Graphics Girvin
5 08/30/10 Protein structure determination and the PDB II Almo
6 08/31/10 Protein structure determination and the PDB II Almo
7 09/01/10 Protein purification Bresnick
8 09/02/10 Protein characterization and analysis Bresnick

09/03/10 Tutorial

09/06/10 Labor Day
9 09/07/10 Proteomics I Bresnick
10 09/08/10 Proteomics II Bresnick

09/09/10 Rosh Hashanah

09/10/10 Rosh Hashanah
11 09/13/10 Ligand binding I Bresnick
12 09/14/10 Ligand binding II Bresnick
13 09/15/10 Protein folding Callender
14 09/16/10 Protein dynamics Callender

09/17/10 Tutorial
15 09/20/10 Protein misfolding (and disease) Callender
16 09/21/10 Structure and energetics of nucleic acids I Levy
17 09/22/10 Structure and energetics of nucleic acids II Levy

09/23/10 Yom Kippur

09/24/10 Yom Kippur
18 09/27/10 Structure and energetics of nucleic acids III Levy
19 09/28/10 Structure and energetics of nucleic acids IV Levy
20 09/29/10 Biological lipids and their properties Silver

09/30/10 Shemini Atzeret

10/01/10 Simchat Torah
21 10/04/10 Membrane function Silver
22 10/05/10 Fatty acids: Biosynthesis, metabolism, and transport Silver
23 10/06/10 Cholesterol: Biosynthesis, metabolism and transport Silver
24 10/07/10 Carbohydrates I Wu

10/08/10 Exam 1; Lectures 2-19, Forch 1st Flr Lecture Hall, 8:20 am
25 10/11/10 Carbohydrates II Wu
26 10/12/10 Carbohydrates III Wu
27 10/13/10 Enzymatic catalysis I Lai
28 10/14/10 Enzymatic catalysis II Lai

10/15/10 Tutorial & Protein Project – Presentations 1-4, 708 Belfer


Part II: Macromolecular function








29 10/18/10 Enzymatic catalysis III Lai
30 10/19/10 Enzymatic catalysis IV Lai
31 10/20/10 Metabolism I Lai
32 10/21/10 Metabolism II Lai

10/22/10 Protein Project – Presentations 5-8, 708 Belfer
33 10/25/10 Allostery and regulation Lai
34 10/26/10 Signal transduction I Schmidt
35 10/27/10 Signal transduction II Schmidt
36 10/28/10 Chaperones and protein folding Schmidt

10/29/10 Tutorial & Protein Project – Presentations 9-12, 802 Belfer
37 11/01/10 Regulated protein turnover I Schmidt
38 11/02/10 Regulated protein turnover II Schmidt
39 11/03/10 Protein:nucleic acid interactions – assembly of large complexes Levy
40 11/04/10 DNA processing enzymes – restriction/modification (epigenetics) Levy

11/05/10 Exam 2; Lectures 20-38, Forch 3rd Flr Lecture Hall, 8:20 am
41 11/08/10 Eukaryotic chromatin structure, assembly and dynamics Shechter
42 11/09/10 The histone code and regulation of gene expression Shechter
43 11/10/10 Principles of DNA repair Shechter
44 11/11/10 Principles of DNA replication Willis

11/12/10 Tutorial & Protein Project – Presentations 13-16, 802 Belfer
45 11/15/10 Principles of prokaryotic transcription Willis
46 11/16/10 Principles of transcription regulation Willis
47 11/17/10 Transcription in eukaryotes: the basal machinery Willis
48 11/18/10 Transcription in eukaryotes: activation mechanisms Willis

11/19/10 Tutorial
49 11/22/10 Transcription in eukaryotes: conclusion Willis
50 11/23/10 Principles of protein translation I Almo
51 11/24/10 Principles of protein translation II Almo

11/25/10 Thanksgiving

11/26/10 Thanksgiving
52 11/29/10 RNA maturation Almo
53 11/30/10 Principles of protein translation III Almo
54 12/01/10 Principles of protein translation IV Almo

12/03/10 Tutorial


MSTP Anatomy exam - all day


Exam 3 (lectures 39-54), Forch 3rd Flr Lecture Hall, 8:20 am