• Vetting MW, Hegde SS, Blanchard JS. (2009) "Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde." Acta Crystallogr D Biol Crystallogr. 65(Pt 5), 462-9.
• Tremblay LW, Fan F, Vetting MW, Blanchard JS (2008) "The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway."
  Biochemistry. 47(50):13326-35.
• Vetting MW, Errey JC, Blanchard JS. (2008) " Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold."
  Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 11):978-85
• Vetting MW, Park CH, Hegde SS, Jacoby GA, Hooper DC, Blanchard JS. (2008) "Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant." Biochemistry. 47(37):9825-35.
• Vetting MW, Bareich DC, Yu M, Blanchard JS. (2008) "Crystal structure of RimI from Salmonella typhimurium LT2, the GNAT responsible for N(alpha)-acetylation of ribosomal protein S18." Protein Sci. 17(10):1781-90.
• Vetting MW, Frantom PA, Blanchard JS. (2008) "Structural and enzymatic analysis of MshA from corynebacterium glutamicum: Substrate-assisted catalysis." J Biol Chem. 283(23):15834-44.
• Magalhães ML, Vetting MW, Gao F, Freiburger L, Auclair K, Blanchard JS. (2008) "Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6'-N-Acetyltransferase." Biochemistry. 47(2):579-84.
• Argyrou A, Vetting MW, Blanchard JS. (2007) "New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP."
  J Am Chem Soc. 129(31):9582-3.
• Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. (2007) "Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase." Biochemistry. 46(24):7187-95.
• Olsen LR, Vetting MW, Roderick SL. (2007) "Structure of the E. coli bifunctional GlmU acetyltransferase active site with substrates and products." Protein Sci. 16(6):1230-5.
• Andreassi JL 2nd, Bilder PW, Vetting MW, Roderick SL, Leyh TS. (2007) "Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate."
  Protein Sci. 16(5):983-9.
• Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS. (2007) "Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein." Protein Sci. 16(4):755-60.
• Argyrou A, Vetting MW, Aladegbami B, Blanchard JS. (2006) "Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid." Nat Struct Mol Biol. 13: 408 - 413
• Vetting MW, Hegde SS, Fajardo JE, Fiser A, Roderick SL, Takiff HE, Blanchard JS. (2006) "Pentapeptide Repeat Proteins." Biochemistry. 45(1):1-10
• Vetting MW, Yu M, Rendle PM, Blanchard JS. (2006) "The Substrate-induced Conformational Change of Mycobacterium tuberculosis Mycothiol Synthase." J Biol Chem. 281(5):2795-802
• Earhart CA, Vetting MW, Gosu R, Michaud-Soret I, Que L Jr, Ohlendorf DH. (2005) "Structure of catechol 1,2-dioxygenase from Pseudomonas arvilla. Biochem Biophys Res Commun. 338(1):198-205.
• Valley MP, Brown CK, Burk DL, Vetting MW, Ohlendorf DH, Lipscomb JD. (2005) "Roles of the equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis."
  Biochemistry. 44(33):11024-39.
• Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS. (2005)
  "A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA."
  Science. 308(5727):1480-3.
• Vetting MW, de Carvalho LP, Roderick SL, Blanchard JS. (2005) "A Novel Dimeric Structure of the RimL Na-acetyltransferase from Salmonella typhimurium." J Biol Chem. 280(23):22108-14.
• Vetting MW, S de Carvalho LP, Yu M, Hegde SS, Magnet S, Roderick SL, Blanchard JS. (2005) "Structure and functions of the GNAT superfamily of acetyltransferases.
  Arch Biochem Biophys. 433(1):212-26.
• Brown CK, Vetting MW, Earhart CA, Ohlendorf DH. (2004) "Biophysical analyses of designed and selected mutants of protocatechuate 3,4-dioxygenase."
  Annu Rev Microbiol. 58:555-85.
• Argyrou A, Vetting MW, Blanchard JS. (2004) "Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis."
  J Biol Chem. 279(50):52694-702.
• Olsen L.R, Huang B, Vetting MW, Roderick SL, (2004) "Structure of Serine Acetyltransferase in Complexes with CoA and Its Cysteine Feedback Inhibitor."
  Biochemistry, 43(20):6013-9.
• Vetting MW, Magnet S, Nieves E, Roderick SL, Blanchard JS. (2004) "A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones."
  Chemistry & Biology, 11(4):565-73.
• Vetting MW, Wackett LP, Que L Jr, Lipscomb JD, Ohlendorf DH. (2004) "Crystallographic comparison of manganese- and iron-dependent homoprotocatechuate 2,3-dioxygenases."
  J Bacteriol. 2004, 186(7):1945-58.
• Vetting MW, Roderick SL, Yu M, Blanchard JS. (2003). Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases. Protein Science, 12(9):1954-9.
• Vetting M, Roderick SL, Hegde S, Magnet S, Blanchard JS. (2003). What can structure tell us about in vivo function? The case of aminoglycoside-resistance genes.
  Biochem Soc. Trans.31(Pt 3):520-2.
• Vetting MW, Hegde SS, Javid-Majd F, Blanchard JS, Roderick SL. (2002). Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nature Structural Biology, 9(9):653-8.
• Roderick SL, Chan WW, Agate DS, Olsen LR, Vetting MW, Rajashankar KR, Cohen DE. (2002) Structure of human phosphatidylcholine transfer protein in complex with its ligand.
  Nature Structural Biology, 9(7):507-11.
• Ohlendorf, D.H., & Vetting, M.W. (2001). Protocatechuate 3,4-Dioxygenase.
  Contribution for: Handbook of Metalloproteins. Volume 1, ISBN: 0-471-62743-7
• Vetting MW, D'Argenio DA, Ornston LN, Ohlendorf DH. (2000) Structure of Acinetobacter strain ADP1 protocatechuate 3, 4-dioxygenase at 2.2 Å resolution: implications for the mechanism of an intradiol dioxygenase. Biochemistry. 39(27): 7943-55.
• Vetting, M.W., & Ohlendorf, D.H., (2000). The 1.8 Å Crystal Structure of Catechol 1,2-Dioxygenase Reveals a Novel Hydrophobic Helical Zipper as a Subunit Linker.
  Structure Folding & Design, 8(4), 429-40
• D'Argenio, D.A., Vetting, M.W., Ohlendorf, D.H., & Ornston, L.N. (1999). Substitution, Insertion, Deletion, Suppression, and Altered Substrate Specificity in Functional Protocatechuate 3,4-Dioxygenases.
  J. Bact., 181, 6478-6487
• Vetting, M.W., Earhart, C.A., & Ohlendorf, D.H. (1994). Crystallization and Preliminary X-ray Analysis of Protocatechuate 3,4-Dioxygenase from Acinetobacter calcoaceticus.
  J. Mol. Biol., 236, 372-373

Seminar Presentations

• "The Pentapeptide Repeat Fold and Fluroquinolone Resistance " 9th Annual Summer Meeting, New York Structural Biology Group, (July 19, 2006)
• "Structural Studies of Aminoglycoside Acetyltransferases, What Can Structure Tell us About in vivo Function?" Department of Pathology, New York Medical College (Dec 14, 2003)
• "A Comparison of the X-Ray Crystal Structures of Intradiol and Extradiol Dioxygenases" to the Metalloprotein Interest Group, University of Minnesota (June 1, 1999)
• "Structural Studies of Homoprotocatechuate 2,3-Dioxygenase" to the Metalloprotein Interest Group, University of Minnesota (May 5, 1998)
• "Structural Studies of Protocatechuate 3,4-Dioxygenase and Related Enzymes" to the Metalloprotein Interest Group, University of Minnesota (June 6, 1996)

• 2004 Outstanding Postdoctoral Award: Albert Einstein College of Medicine (Sept, 2004)
• Young Scientist Special Interest Group (YSSIG) American Crystallographic Association Chair 2001-2002
• Member of Metalloprotein Interest Group, University of Minnesota
• Linus Pauling Poster Prize Winner ACA Conference for Poster Titled "High Resolution Native and Complex Structures of Catechol 1,2-Dioxygenase from Acinetobacter sp. ADP1." (June, 1999)
• Competitive Biophysics Training Grant (Oct1995 - Oct1998)
• Life Sciences Summer Programs Research Grant (June 92 - Aug 92)
• Undergraduate Research Opportunities Program Grant (Jan 92 - June 92)

• American Crystallographic Association (ACA) Conference, Orlando, FL.. (May, 2005)
• American Crystallographic Association (ACA) Conference, Chicago, IL. (July, 2004)
• American Crystallographic Association (ACA) Conference, Covington, KY. (July, 2003)
• American Crystallographic Association (ACA) Conference, Austin, TX. (July, 2002)
• American Crystallographic Association (ACA) Conference, Los Angeles, CA. (July, 2001)
• American Crystallographic Association (ACA) Conference, St. Paul, MN. (July, 2000)
• ICBIC 9: 9th International Conference on Biological Inorganic Chemistry, Minneapolis, Minnesota. (July 1999)
• American Crystallographic Association (ACA) Conference, Buffalo, N.Y. (June, 1999)
• Proteins Gorden Conference, Tilton, N.H. (June, 1995)
• Protein Engineering and Design, Urbana, Il (June, 1994)
• Protein Engineering and Design, Urbana, Il (June, 1993)

• Instructor, AECOM 2007-present
• Postdoctoral Research Associate, AECOM; 2001-2007
• University of Minnesota, Twin Cities; Ph.D. (2001)
• University of Minnesota, Twin Cities; B.S. Biochemistry (1988-1993)

• Teaching Assistant, Department of Biochemistry, University of Minnesota, Winter 95, Biochemistry for Medical Technicians
• Teaching Assistant, Department of Biochemistry, University of Minnesota, Spring 94, 2nd Quarter of Biochemistry for Medical Students
• Laboratory Technician, Department of Biochemistry, University of Minnesota (Jan91 - Sept 93)

Protein Overexpression

Protein Purification

• Under Oil
• Hanging Drop
• Sitting Drop
• Batch
• Seeding

Crystal Preperation

Data Collection