Tremblay LW, Hugonnet JE, Blanchard JS. (2008) "Structure of the Covalent Adduct Formed between Mycobacterium tuberculosis beta-Lactamase and Clavulanate." Biochemistry. 47(19), 5312-6.
Vetting MW, Frantom PA, Blanchard JS. (2008) "Structural and enzymatic analysis of MshA from corynebacterium glutamicum: Substrate-assisted catalysis." J Biol Chem. Apr 4. [Epub ahead of print]
Williams L, Fan F, Blanchard JS, Raushel FM. (2008) Positional Isotope Exchange Analysis of the Mycobacterium smegmatis Cysteine Ligase (MshC). Biochemistry. Mar 29. [Epub ahead of print]
Magalhães ML, Vetting MW, Gao F, Freiburger L, Auclair K, Blanchard JS. (2008) "Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6'-N-Acetyltransferase." Biochemistry. 47(2):579-84.
Hugonnet JE, Blanchard JS. (2007) "Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate." Biochemistry. 46(43):11998-2004
Pillai B, Cherney M, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. (2007) "Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase."
Biochem Biophys Res Commun. 363(3):547-53.
Fan F, Luxenburger A, Painter GF, Blanchard JS. (2007) "Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC)." Biochemistry. 46(40):11421-9.
Argyrou A, Vetting MW, Blanchard JS. (2007) "New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP."
J Am Chem Soc. 129(31):9582-3.
Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. (2007) "Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase." Biochemistry. 46(24):7187-95. .
Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS. (2007) "Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein." Protein Sci. 16(4):755-60.
Yu M, Magalhaes ML, Cook PF, Blanchard JS. (2006) " Bisubstrate inhibition: Theory and application to N-acetyltransferases." Biochemistry. 45(49):14788-94.
Yu M, de Carvalho LP, Sun G, Blanchard JS. (2006) "Activity-based substrate profiling for Gcn5-related N-acetyltransferases: the use of chloroacetyl-coenzyme A to identify protein substrates."
J Am Chem Soc. 128(48):15356-7.
Argyrou A, Jin L, Siconilfi-Baez L, Angeletti RH, Blanchard JS. (2006) "Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis." Biochemistry. 45(47):13947-53.
Silva RG, de Carvalho LP, Blanchard JS, Santos DS, Basso LA. (2006) "Mycobacterium tuberculosis beta-Ketoacyl-Acyl Carrier Protein (ACP) Reductase: Kinetic and Chemical Mechanisms."
Biochemistry. 31;45(43):13064-13073.
Wing C, Errey JC, Mukhopadhyay B, Blanchard JS, Field RA. (2006) "Expression and initial characterization of WbbI, a putative d-Galf:alpha-d-Glc beta-1,6-galactofuranosyltransferase from Escherichia coli K-12." Org Biomol Chem. 4(21):3945-50.
de Carvalho LP, Blanchard JS. (2006) "Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis." Biochemistry. 45(29):8988-99.
Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. (2006) "Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target." Proc Natl Acad Sci U S A. 103(23):8668-73.
de Carvalho LP, Blanchard JS. (2006) "Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis alpha-isopropylmalate synthase."
Arch Biochem Biophys. 451(2):141-8.
Argyrou A, Vetting MW, Aladegbami
B, Blanchard JS. (2006) "Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid." Nat
Struct Mol Biol. 13: 408 - 413
Errey JC, Blanchard JS. (2006) "Functional
Annotation and Kinetic Characterization of PhnO from Salmonella
enterica." Biochemistry.
45(9):3033-9.
Vetting MW, Hegde SS, Fajardo JE, Fiser
A, Roderick SL, Takiff HE, Blanchard JS. (2006) "Pentapeptide
Repeat Proteins."
Biochemistry. 45(1):1-10
Vetting MW, Yu M, Rendle PM, Blanchard
JS. (2006) "The Substrate-induced Conformational
Change of Mycobacterium tuberculosis Mycothiol Synthase."
J
Biol Chem. 281(5):2795-802
Magalhaes ML, Blanchard JS. (2005)
"The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase
from Escherichia coli."
Biochemistry. 44(49):16275-83
Diaper CM, Sutherland A, Pillai B, James
MN, Semchuk P, Blanchard JS, Vederas JC. (2005) "The
stereoselective synthesis of aziridine analogues of diaminopimelic
acid (DAP) and their interaction with dap epimerase."
Org
Biomol Chem. 3(24):4402-11.
Blanchard JS. (2005) "Old approach
yields new antibiotic." Nat
Med. 11(10):1045-6.
de Carvalho LP, Argyrou A, Blanchard JS.
(2005) "Slow-onset feedback inhibition: inhibition of
Mycobacterium tuberculosis alpha-isopropylmalate synthase
by L-leucine."
J
Am Chem Soc. 127(28):10004-5.
Hegde SS, Vetting MW, Roderick SL, Mitchenall
LA, Maxwell A, Takiff HE, Blanchard JS. (2005)
"A fluoroquinolone resistance protein from Mycobacterium
tuberculosis that mimics DNA."
Science.
308(5727):1480-3.
Errey JC, Blanchard JS. (2005) "Functional
characterization of a novel ArgA from Mycobacterium tuberculosis."
J
Bacteriol. 187(9):3039-44.
Vetting MW, de Carvalho LP, Roderick SL, Blanchard JS.
(2005) "A Novel Dimeric Structure of the RimL Na-acetyltransferase
from Salmonella typhimurium." J
Biol Chem. 280(23):22108-14.
Magnet S, Blanchard JS. (2005) "Molecular
insights into aminoglycoside action and resistance."
Chem
Rev. 105(2):477-98.
Vetting MW, S de Carvalho LP, Yu M, Hegde
SS, Magnet S, Roderick SL, Blanchard JS. (2005) "Structure
and functions of the GNAT superfamily of acetyltransferases.
Arch
Biochem Biophys. 433(1):212-26.