Blanchard Lab
Renjain Zheng
Department of Biochemistry
315 Forcheimer Bldg.
1300 Morris Park Avenue
Bronx, NY 10461-1602
REFERENCES
(718) 430-3095
zheng@aecom.yu.edu

Zheng R, Dam TK, Brewer CF, Blanchard JS. (2004) "Residues in Mycobacterium tuberculosis Pantothenate Synthetase Required in the Formation and Stabilization of the Adenylate Intermediate."
Biochemistry. 8;43(22):7171-8.

Zheng R, Blanchard JS. (2003) "Substrate specificity and kinetic isotope effect analysis of the Eschericia coli ketopantoate reductase." Biochemistry, 42(38):11289-96

Cirilli M, Zheng R, Scapin G, Blanchard JS. (2003). "The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity." Biochemistry, 42(36):10644-50.

Vogt RN, Steenkamp DJ, Zheng R, Blanchard JS. (2003). "The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase." Biochem J. 374(Pt 3):657-66.

Williams L, Zheng R, Blanchard JS, Raushel FM. (2003). "Positional isotope exchange analysis of the pantothenate synthetase reaction." Biochemistry, 42(17):5108-13.

Magnet S, Smith TA, Zheng R, Nordmann P, Blanchard JS. (2003) "Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase."
Antimicr
ob Agents Chemother. 47(5):1577-83.

Sugantino M, Zheng R, Yu M, Blanchard JS. (2003), "Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids." Biochemistry, 42(1):191-9.

Zheng R, Blanchard JS. (2001) "Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase." Biochemistry, 40(43):12904-12.

Zheng R, Blanchard JS. (2000) "Identification of active site residues in E. coli ketopantoate reductase by mutagenesis and chemical rescue." Biochemistry. 39(51):16244-51.

Caplan JF, Zheng R, Blanchard JS, Vederas JC. "Vinylogous amide analogues of diaminopimelic acid (DAP) as inhibitors of enzymes involved in bacterial lysine biosynthesis." Org Lett. 2(24):3857-60.

Zheng R, Blanchard JS. (2000) "Kinetic and mechanistic analysis of the E. coli panE-encoded ketopantoate reductase. Biochemistry. 39(13):3708-17.

Cirilli M, Zheng R, Scapin G, Blanchard JS. (1998) "Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase." Biochemistry. 37(47):16452-8.

Basso LA, Zheng R, Musser JM, Jacobs WR Jr, Blanchard JS. (1998) "Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. J Infect Dis. 178(3):769-75.

Born TL, Zheng R, Blanchard JS. (1998) "Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism." Biochemistry. 21;37(29):10478-87.

Scapin G, Reddy SG, Zheng R, Blanchard JS. (1997) "Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate."
Biochemistry. 36(49):15081-8.

Zheng R, Cenas N, Blanchard JS. (1995) "Catalytic and potentiometric characterization of E201D and E201Q mutants of Trypanosoma congolense trypanothione reductase." Biochemistry. 34(39):12697-703.