Department of Biochemistry
315 Forchheimer Bldg.
1300 Morris Park Avenue
Bronx, NY 10461-1602

Saugata Hazra

Saugata Hazra, Szewczak A., Ort S., Konrad M., Arnon Lavie.: “Posttranslational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside
binding and release. ”, Biochemistry. 2011 Feb 25 [Epub ahead of print].

Saugata Hazra, Konrad M., Arnon Lavie.: “The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK activated acyclic guanine analogues.”Journal of Medicinal Chemistry. 2010 Aug 12; 53(15):5792-800.

Saugata Hazra, Ort S., Konrad M., Arnon Lavie.: “Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5- substituted deoxycytidine and thymidine analogues.” Biochemistry. 2010 Aug 10; 49(31):6784-90.

Saugata Hazra, Sabini E., Ort S., Konrad M., Arnon Lavie.: “Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase” Biochemistry. 2009 Feb 17; 48(6):1256-63.

Sabini E, Saugata Hazra, Konrad M., Arnon Lavie.: “Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase”Journal of Medicinal Chemistry. 2008 Jul 24; 51(14): 4219-25.

Sabini E., Saugata Hazra, Ort S., Konrad M., Arnon Lavie.: “Structural basis for substrate promiscuity of dCK” Journal of Molecular Biology. 2008 May 2;378(3):607-21.

Theresa McSorley, Stephan Ort, Saugata Hazra, Arnon Lavie, Manfred Konrad: “Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues” FEBS Letter.2008 Mar 5; 582(5):720-4.

E Sabini, Saugata Hazra, Manfred Konrad, Arnon Lavie: “Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.” Journal of Medicinal Chemistry. 2007 Jun 28; 50(13): 3004-14.

E Sabini, Saugata Hazra , Manfred Konrad, Arnon Lavie : “Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase”. Nucleic Acid Research. 2007; 35(1): 186-92 ( * This paper was honoured to have the cover picture)