Department of Biochemistry
315 Forchheimer Bldg.
1300 Morris Park Avenue
Bronx, NY 10461-1602

Fan Fan

Fan F, Vetting MW, Frantom PA, Blanchard JS. (2009) "Structures and mechanisms of the mycothiol biosynthetic enzymes." Curr Opin Chem Biol. 13(4):444-52.

Fan, F. , and Blanchard, J. S. (2009) "Towards the Catalytic Mechanism of a Cysteine Ligase (MshC) from Mycobacterium smegmatis : An Enzyme Involved in the Biosynthetic Pathway of Mycothiol" Biochemistry , Epub ahead of print.

Tremblay LW, Fan F, Vetting MW, Blanchard JS (2008) "The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway."
Biochemistry. 47(50):13326-35.

Williams L, Fan F, Blanchard JS, Raushel FM. (2008) Positional Isotope Exchange Analysis of the Mycobacterium smegmatis Cysteine Ligase (MshC). Biochemistry. 47(16):4843-50.

Quaye, O., Lountos, G. T., Fan, F., Orville, A. M., and Gadda, G. (2008) "Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase." Biochemistry. 47, (1) 243-56.

Fan, F., and Gadda, G. (2007) An Internal Equilibrium Preorganizes the Enzyme-Substrate Complex for Hydride Tunneling in Choline Oxidase. Biochemistry. 46 (21), 6402-8.

Fan F, Luxenburger A, Painter GF, Blanchard JS. (2007) "Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC)." Biochemistry. 46(40):11421-9.

Gadda G, Fan F, Hoang JV. (2006) "On the contribution of the positively charged headgroup of choline to substrate binding and catalysis in the reaction catalyzed by choline oxidase."
Arch Biochem Biophys. 451(2):182-7.

Fan F, Germann MW, Gadda G. (2006) "Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde."
Biochemistry. 45(6):1979-86.

Fan F, Gadda G. (2005) "Oxygen- and temperature-dependent kinetic isotope effects in choline oxidase: correlating reversible hydride transfer with environmentally enhanced tunneling."
J Am Chem Soc. 127(50):17954-61.

Fan F, Gadda G. (2005) "On the catalytic mechanism of choline oxidase."
J Am Chem Soc. 127(7):2067-74.

Fan F, Ghanem M, Gadda G. (2004) "Cloning, sequence analysis, and purification of choline oxidase from Arthrobacter globiformis: a bacterial enzyme involved in osmotic stress tolerance."
Arch Biochem Biophys. 421(1):149-58.

Ghanem M, Fan F, Francis K, Gadda G. (2003) "Spectroscopic and kinetic properties of recombinant choline oxidase from Arthrobacter globiformis."
Biochemistry. 42(51):15179-88.

Powell, N., Fan, F., Wilkins, L., and Gadda,G. (2002) "Comparative Study of Choline Oxidizing Enzymes from Escherichia coli, Halomonas elongata, and Arthrobacter globiformis" in Flavins and Flavoproteins 2002 (Perham, R.N., Chapman, S.K., Scrutton, N.S., eds.). Rudolf Weber, Berlin, Germany. pp. 149-54.